Several pharmaceutical companies are currently testing TGF?-blocking compounds in clinical trials as candidate drugs against breast cancer, melanoma and other types of cancer. This new advance confirms the possibility to develop drugs that interfere with the action of TGF? in order to prevent and treat cancer metastasis. In addition, the study also points to Angiopoietin as another potential target to interrupt TGF?-induced stimulation of metastasis without interfering with the beneficial effects of this cytokine on the body. According to Cristina Nadal, several components are needed to obtain these results, among others, a daily effort of collaboration between clinicians and scientists in basic research, a common motivation to understand the mechanisms of metastasis formation and a practical spirit addressed to find drugs to prevent its growth.

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